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Dilution Calculator Dilution Calculator Calculate the dilution required to prepare a stock solution. Molecular Weight Calculator Molecular Weight Calculator Enter the chemical formula of a compound to calculate its molar mass and elemental dwtasheet Choose Selective Histone Methyltransferase Inhibitors. Bio Calculators Molarity Calculator Molarity Calculator Calculate the mass, volume or concentration required for a solution.
Molecular mass molecular weight is the mass of one molecule of a substance and is expressed in the unified atomic mass units u.
The Selleck dilution calculator is based on datasheef following equation:. Prolonged treatment 38 days with MI induces no toxicity in mice as reflected by no alterations in the body weight and no morphological changes in liver and kidney tissues. These effects are accompanied by reduced c-kit CD expression, a marker associated with leukemia stem cells LSCs. Not for human use.
BCR Datasheet(PDF) – Siemens Semiconductor Group
MI could substantially improve survival of MLL leukemic mice and does not impair normal hematopoiesis in vivo . The cell growth inhibitory effect of MI is time-dependent, with a pronounced effect achieved after days of treatment. The Selleck molarity calculator is based on the bfr equation: Products are for research use only.
It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines GI50 at nM nM rangebut only a minimal effect in human leukemia cell lines without MLL translocations. It blocks hematologic tumors in vivo and reduces MLL leukemia tumor burden.
This equation is commonly abbreviated as: Topics include how to prepare eatasheet solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
For viability assays, leukemia cells are eatasheet at relevant concentrations and treated with compounds or 0. This is normal and is due to slight batch-to-batch variations.
MI has very favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice. The Selleck molarity calculator is based on the following equation:.
The Selleck dilution calculator is based on the following equation: Calculate the mass, volume or concentration required for a solution. References  Borkin D, et al. Answers to questions you may have can be found in the inhibitor handling instructions.
Media is changed at day 4, viable cell numbers are restored to the original concentration and compounds are re-supplied. For cell differentiation studies, leukemia cells are treated with menin-MLL inhibitors for 7 days, then harvested, washed and incubated with Pacific Blue rat anti-mouse CD11b antibody before being analyzed by flow cytometry.
BCR503 Datasheet, Equivalent, Cross Reference Search
Calculate the dilution required to prepare a stock solution. Menin-MLL interaction  Cell-free assay.
Treatment with sub-micromolar concentrations of MI also leads to markedly reduced expression of Hoxa9 and Meis1, downstream targets of MLL fusion proteins substantially upregulated in MLL leukemias . Serial Dilutions Concertration start: In vivo MI has very favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice. To calculate molar mass of a chemical compound, please enter its chemical formula and click ‘Calculate’.
Chemical formula is case sensitive. Histone Methyltransferase Signaling Pathway Map. MI is also very effective in inducing differentiation of MLL leukemia cells and substantially increases expression of CD11b, a myeloid differentiation marker. We do not sell to patients. Tech Support Answers to questions you may have can be found in the inhibitor handling instructions.